BMN 673

BMN 673

Author: ApexBio

spu:

A4153

CAS:

1207456-01-6

purity:

0.9926

shortsummary:

Potent PARP inhibitor

909910-43-6 References

Formula:

C19H14F2N6O

M.Wt:

380.35

Chemical Name:

(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

SMILES:

FC1=CC2=C3C([C@H](C4=NC=NN4C)[C@@H](C(C=C5)=CC=C5F)NC3=C1)=NNC2=O

Solubility:

insoluble in H2O; ≥14.2 mg/mL in EtOH with gentle warming and ultrasonic; ≥19.02 mg/mL in DMSO

Storage:

Store at -20°C

Physical Appearance:

A solid

DeliveryTime:

In stock

buy SB 431542

ShippingType:

Blue ice

description:

BMN673 is a potent and selective PARP1/2 inhibitor with Ki of 1.2 and 0.9 nM, respectively ¹. It had no effect on panels of 72 receptors, ion channels, and enzymes ¹. BMN673 showed IC50 value of 0.57 nM in enzymatic assay of PARP1 ¹. In in vitro assay, it exhibited greater potency than other existing PARP inhibitors, such as veliparib, rucaparib, and olaparib ². It is also much more potent at trapping PARP-DNA complexes than other PARP inhibitors ³.

related websites:

APExBIO Technology LLC is a premier provider of Small Molecule Inhibitors/Activators, Compound Libraries, Peptides, Assay Kits, Fluorescent Labels, Enzymes, Modified Nucleotides, mRNA synthesis and various tools for Molecular Biology. We carry a broad product line in over 1189 different research areas such as cancer, immunology, neurosciences, apoptosis and epigenetics etc. Based in USA (Houston, Texas), we have been serving the needs of customers across the world.